The West Wing stars are to campaign for Hillary Clinton in Ohio this weekend.
Allison Janney, Richard Schiff, Dule Hill, Bradley Whitford, Joshua Malina, and Mary McCormack will reunite to help organize events across the state.
The stars of the former hit political TV drama will appear in towns including Cleveland, Sandusky and Toledo.
The West Wing, also starring Martin Sheen, ran on NBC from 1999 to 2006.
Martin Sheen played Democratic President Josiah Bartlet in the Golden Globe-winning drama, played out within the enclaves of the White House.
His former co-stars will go on the Clinton campaign trail to rally the public to vote, according to a campaign statement.
“The actors will discuss why they are supporting Clinton and urge Ohioans to register to vote ahead of the 11 October deadline and to get involved in organizing their communities ahead of November’s election,” the statement said.
Martin Sheen however won’t be joining his former West Wing colleagues, neither will Rob Lowe, one of the drama’s other main stars.
He has nonetheless previously stated his support for Hillary Clinton – and been damning of her Republican rival, Donald Trump.
Martin Sheen also appears in a new anti-Trump video called Save the Day made by the Avengers director Joss Whedon.
Over the course of its long run, The West Wing and its cast were honored several times by the Golden Globes and the Emmys.