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Smoking harms almost every part of the body, including the skin, eyes, circulatory system, respiratory system, and even the reproductive system. Smoking also causes an increased risk of many different diseases, including cancer and diabetes.

Each year in the United States, almost 500,000 people die from tobacco use-related illnesses. In fact, smoking cigarettes kills more Americans than car accidents, alcohol, guns, illegal drugs, and HIV combined.

Here are seven ways that smoking impacts your health. By switching to a tobacco alternative, you can get the nicotine you need without the tobacco.

1. Lung Damage

When a cigarette is inhaled, nicotine and dozens of other chemicals are introduced into the respiratory system. Smokers are at a 25 times higher risk of developing lung cancer than non-smokers.

Aside from an increased risk of lung damage that may lead to lung cancer, smoking also increases the risk of chronic bronchitis, emphysema, and chronic obstructive pulmonary disorder (COPD). In all cases of COPD, 9 out of 10 are linked to smoking.

Smoking also damages the airways, which contributes to the infamous smoker’s cough.

2. Damage to Cardiovascular System

While there are many factors that increase the risk of heart disease, smoking is one of the top lifestyle habits that contribute to the disease. Those who smoke, as well as those who are exposed to secondhand smoke, are at an increased risk of heart disease and heart attacks.

Tobacco smoke also lowers good cholesterol (HDL) levels in the body, while increasing bad cholesterol (LDL). Tobacco smoke has also been linked to increased triglycerides and total cholesterol in the blood.

Nicotine causes blood vessels to tighten, which restricts blood flow throughout the body. This increases the risk of stroke, heart attack, and high blood pressure.

3. Damaged Immune System

Smokers are more likely to have more respiratory tract infections when compared to people who don’t smoke. This is not only because smoking damages the lungs, but it also impacts the immune system’s ability to fight off infections.

This means that smokers will experience more severe and longer-lasting illnesses. Smoking has also been linked to lower levels of antioxidants in the blood, including vitamin C.

Smoking also increases inflammation throughout the body.

4. Vision Problems

While your vision may not be impacted immediately, smoking has shown to have negative effects on the eyes. Long-term smokers are likely to experience future vision problems, including cataracts, macular degeneration, and glaucoma.

Smoking also increases the risk of damage to the optic nerve. This is the nerve that connects the eye to the brain. Excessive damage to the optic nerve can cause blindness.

In the short-term, smokers are likely to experience dry eyes, which makes the eyes red and scratchy.

5. Fertility & Reproductive System Issues

Smoking damages both the male and female reproductive systems. For men, smoking increases the risk of erectile dysfunction. Smoking also negatively impacts the quality of sperm, which reduces fertility.

For women, smoking can make it much more difficult to get pregnant. This is often attributed to tobacco and the many other chemicals that are found in cigarettes. These chemicals impact hormone levels, which then impact fertility. Women also experienced an increased risk of developing cervical cancer.

Smoking also has profound impacts on pregnant women as well as the developing fetus. Common complications include:

  • Increased risk of preterm delivery
  • Increased risk of ectopic pregnancy
  • Reduced birth weight
  • Damage to the baby’s brain, lungs, and central nervous system
  • Increased risk of congenital abnormalities, such as cleft palate and cleft lip
  • Increased risk of sudden infant death syndrome

6. Impacted Digestive System

Smoking suppresses the appetite because it decreases your sense of taste. This makes eating a lot less enjoyable because you can’t taste the food that you’re putting into your mouth.

Smoking has been linked to many different cancers, including cancer of the mouth, throat, esophagus, and larynx. There’s also an increased risk of pancreatic cancer.

Smokers are also more likely to develop insulin resistance, because of how smoking impacts insulin. Insulin resistance increases the risk of type 2 diabetes, along with the many complications associated with the disease.

7. Damaged Hair, Skin, & Nails

Smoking impacts the hair, skin, and nails in many ways. Smokers are at an increased risk of hair loss, balding, and early graying. This is due to the high nicotine content found in cigarettes.

Smoking also visibly impacts the skin. Tobacco smoke changes the structure of the skin, which can lead to dry skin and premature aging. This is because nicotine reduces blood flow, which impacts the skin’s ability to get the nutrition it needs.

People who smoke are also at an increased risk of developing skin cancer.

Routine handling of tobacco products stains the fingers and fingernails a yellow color. Aside from staining, smokers face a higher risk of fungal nail infections.

Conclusion

It’s an understatement to say that smoking has a profound impact on the body. While it’s not easy to quit smoking, doing so can greatly improve your overall health now and long into the future. Quitting smoking is the key to living a happier, longer life.

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A new therapy could profoundly improve cystic fibrosis patients’ quality of life, say doctors.

Patients suffering from cystic fibrosis often die before their 40s as mucus clogs and damages their lungs and leaves them prone to infection.

A major international trial on 1,108 patients, in the New England Journal of Medicine, showed a combination of drugs could bypass the genetic errors that cause the disease and may increase life expectancy.

Errors in sufferers’ DNA – inherited from their parents – damage the microscopic machinery that controls salt and water levels in the linings of the lungs.Cystic fibrosis new therapy

The result is a thick mucus that inexorably damages the lungs.

Antibiotics help prevent infection and drugs can loosen the mucus, but nothing deals with the fundamental problem for most patients.

The combination of drugs – lumacaftor and ivacaftor – were designed to repair that microscopic machinery.

The trial showed that those patients given the cocktail for 24 weeks had better lung function.

Cystic fibrosis also affects the mucus lining in the gut so the doctors were pleased to see the patients also gained weight in the trial.

There are however, many types of error in the DNA that can culminate in cystic fibrosis.

This treatment combination should work on around half of patients, while one of the drugs on its own corrects a small proportion of errors.

New treatments are still required for the remaining patients.

The therapy is being examined by regulators around the world.

AstraZeneca, the second largest drugs company in UK, has announced it is buying California-based Pearl Therapeutics in a deal worth up to $1.15 billion.

Privately-owned Pearl specializes in drugs used in the treatment of lung disease and asthma.

AstraZeneca said it will pay $560 million initially, then $450 million subject to drug development milestones being reached.

It could also make sales-related payments of up to $140 million in addition.

The acquisition will give AstraZeneca a foothold in the emerging market for a new class of lung treatments known as LABA/LAMA drugs, administered via an inhaler.

AstraZeneca has announced it is buying California-based Pearl Therapeutics in a deal worth up to $1.15 billion

AstraZeneca has announced it is buying California-based Pearl Therapeutics in a deal worth up to $1.15 billion

These drugs are used in the treatment of chronic obstructive pulmonary disease, which affects about 210 million people worldwide.

Anglo-Swedish AstraZeneca, under its new chief executive Pascal Soriot, who took over in October 2012, has identified respiratory treatments as one of its core businesses.

AstraZeneca has been suffering falling profits and sales as several of its blockbuster drugs, such as the anti-psychotic Seroquel and anti-cholesterol Crestor, have lost their patent protection, allowing cheaper generic drugs to enter the market.

It was also forced to write off $140 million relating to a failed arthritis drug.

AstraZeneca is simplifying its drug development programme, cutting 5,000 jobs by 2016, and is looking to expand through acquisitions instead.

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