ZMapp, the experimental drug given to Dr. Kent Brantly and Nancy Writebol to fight the Ebola virus, seems to be working, according to health specialists.
The untested drug was developed by San Diego-based Mapp Biopharmaceuticals.
What we need to know about ZMapp:
1. ZMapp is made from tobacco leaves
ZMapp is made from the leaves of modified tobacco plants, specifically, the Nicotiana benthamiana plant, Bloomberg reported. The tobacco leaves, which typically do more harm than good in regard to human health, help combat the Ebola virus because of the compound that’s created from their modification. The combination of compounds in ZMapp includes a compound called MB-003 and another called ZMAb. MB-003 protected 100% of monkeys exposed to the Ebola virus immediately after exposure. ZMAb provided 100% survival to monkeys one day after exposure. That number decreased to 50% after two days, according to NBC News. Erica Ollmann Saphire, a professor of immunology at the Scripps Research Institute in La Jolla, California, said that one of the antibodies in the serum helps alert the immune system to the presence of infected cells so they can be destroyed. The other two antibodies seem, “to neutralize the virus,” Prof. Erica Ollman Saphire told WebMD.
ZMapp, the experimental drug given to Dr. Kent Brantly and Nancy Writebol to fight the Ebola virus, seems to be working
2. ZMapp had never before been tested in humans
The drug had never been tried before in humans with Ebola, but had shown promise in monkeys with the disease. Both Dr. Kent Brantly and Nancy Writebol knew the drug had never been tested in humans before taking it. Their improving conditions have left researchers optimistic about the effectiveness of ZMapp. Thomas Geisbert, a professor of infectious disease at The University of Texas Galveston Medical Branch, told WebMD: “If we can prove that whatever the treatment was worked, that’s fantastic. That’s exciting. But I’m cautiously optimistic, because with this particular outbreak, almost 40 percent of patients survive without treatment. So we want to make sure that it wasn’t somebody that was going to survive anyway.”
3. ZMapp’s creation was a collaborative effort
ZMapp was the result of collaboration among Mapp Pharmaceuticals, San Diego-based LeafBio, Defyrus in Canada and the Public Health Agency of Canada, according to Times of San Diego.
Mapp Pharmaceuticals said in a statement: “ZMapp was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans. As such, very little of the drug is currently available. Mapp and its partners are cooperating with appropriate government agencies to increase production as quickly as possible.”
4. ZMapp’s use has raised ethical questions
The use of ZMapp has raised ethical questions regarding who has the right to experimental treatment, Bloomberg reported. Robert Garry, a virologist at Tulane University, told the publication: “There are a lot of Africans that are also dying. If we are going to do it for the Americans then we should certainly step up our game for the Africans.”
Liberia’s assistant health minister, Tolbert Nyenswah, told The Wall Street Journal health officials have become inundated with requests from the families of Ebola patients for ZMapp.
5. Mapp Biopharmaceuticals was part of a group awarded a $28 million grant to fight Ebola
Mapp Biopharmaceuticals was one of several companies and research to be selected for a five-year grant of up to $28 million awarded by the National Institutes of Health in order to fight Ebola, according to The Scripps Research Institute.
The Ebola infected US aid workers, Dr. Kent Brantly and Nurse Nancy Writebol, appear to be improving after receiving an experimental drug, officials have said.
It is not clear if the ZMapp drug, which has only been tested on monkeys, can be credited with their improvement.
Dr. Kent Brantly was flown from Liberia to Atlanta for treatment on Saturday. His colleague Nancy Writebol arrived back in the city of Atlanta on Tuesday.
Since February, 887 people have died of Ebola in four West African countries.
The World Bank is allocating $200 million in emergency assistance for countries battling to contain the Ebola outbreak.
Dr. Kent Brantly and Nurse Nancy Writebol’s condition appear to be improving after receiving Ebola experimental serum ZMapp
It is the world’s deadliest outbreak to date and has centered on Guinea, Liberia and Sierra Leone. There have also been two cases in the Nigerian city of Lagos, where eight people are currently in quarantine.
British Airways has temporarily suspended flights to and from Liberia and Sierra Leone until August 31, 2014, because of the health crisis, the airline said in a statement. It follows a similar suspension by two regional air carriers last week.
The Ebola virus spreads by contact with infected blood and bodily fluids. The current outbreak is killing between 50% and 60% of people infected.
There is no cure or vaccine for Ebola – but patients have a better chance of survival if they receive early treatment.
Dr. Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, says clinical trials are to start in September on an Ebola vaccine that has shown promising results during tests on animals.
Dr. Kent Brantly and Nancy Writebol were treated with the ZMapp serum before their evacuation from Liberia.
According to a CNN report, quoting a doctor in Liberia, Dr. Kent Brantly’s condition improved dramatically within an hour of receiving the drug.
Service in Mission (SIM), the Christian aid group that employs Nancy Writebol, says she has had two doses of the drug and did not respond as well as Dr. Kent Brantly but she is showing “improvement”.
“She is walking with assistance… strength is better… has an appetite,” SIM spokesman Palmer Holt told the Washington Post newspaper in an email on Monday.
Nancy Writebol is on her way to a special isolation ward at Atlanta’s Emory University Hospital, where Dr. Kent Brantly is being treated by infectious disease specialists.
British scientists at University of Cambridge say they may have found a more efficient treatment of pancreatic cancer after promising early trial results of an experimental drug combination.
Giving the chemotherapy agent gemcitabine with an experimental drug called MRK003 sets off a chain of events that ultimately kills cancer cells, studies in mice show.
Patients are now testing the treatment to see if it will work for them.
The Cancer Research UK-funded trials are being carried out in Cambridge.
Father-of-two Richard Griffiths, 41, from Coventry, has been on the trial since being diagnosed with pancreatic cancer in May 2011.
“After six cycles of treatment, a scan showed the tumours had reduced and so I have continued with the treatment,” Richard Griffiths said.
“The trial gives you hope – I really feel I can do this with the science behind me.”
Cancer Research UK says it is prioritizing research into pancreatic cancer because the survival rate still remains dismally low.
Survival rates in pancreatic cancer are very low in relation to other cancers, and the length of time between diagnosis and death is typically short, usually less than six months.
The most recent data for UK show that about 16% of patients survive the disease beyond 12 months after diagnosis – prompting the need for new treatments.
Professor Duncan Jodrell, who is leading the trials at the University of Cambridge, said: “We’re delighted that the results of this important research are now being evaluated in a clinical trial, to test whether this might be a new treatment approach for patients with pancreatic cancer, although it will be some time before we’re able to say how successful this will be in patients.”
In total, about 60 patients with advanced pancreatic cancer will be recruited for the first Phase I/II clinical trial.