The Simpsons co-creator Sam Simon has died of colon cancer at the age of 59, his agent announced on March 9.
Sam Simon won seven Emmy awards for his work as a writer, director and executive producer for the longest-running sitcom on American television.
The Simpsons, which chronicles the life of a clumsy father and his dysfunctional family, first aired in 1989.
Sam Simon led the show’s writing staff and is credited with developing the characters that feature in the show.
He left The Simpsons after four seasons, but continued to receive between $20 million to $30 million each year after striking a deal that gave him a part of the show’s future earnings.
After his diagnosis, Sam Simon said he wanted to donate all of his fortune to charity.
Sam Simon gave much of his money to social causes, especially those working on animal welfare issues.
In 2002, he founded the non-profit Sam Simon Foundation which is devoted to rescuing dogs from shelters and training them to assist the disabled.
Sam Simon also worked as a writer for a number of hit sitcoms including Taxi and Cheers.
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VH1’s I Love New York reality star Ahmad “Real” Givens has died after suffering a long battle with colon cancer.
Ahmad Givens, who went on to have his own spin-off series Real Chance of Love with his brother, died on February 20 after a visit from his family.
His brother, Kamal “Chance” Givens, stated Real’s health deteriorated when he fell last month and became bedridden since then, TMZ reported.
Ahmad Givens was diagnosed with stage four colon cancer in 2013. He then proceeded to undergo surgery where his health started to improve.
In 2014, the cancer returned and Ahmad Givens started chemotherapy treatments.
According to Chance, on Friday night Real started to have issues with his speech and eyesight while his family paid him a visit. Hours later Real died.
Robin Gibb apparently showed signs that he might pull through his coma Thursday night.
Robin Gibb, 62, who fell into unconsciousness last week reportedly responded to his elder brother Barry’s voice.
Barry Gibb, 65, sang to Robin by his bedside and a source close to the family said this prompted “flickers of life”.
Speaking to The Sun, the source said: “There were flickers of life from Robin. His eyes moved and there was an attempt at speech.
“It was a good sign he is fighting hard for his life but he is certainly not out of the woods yet.”
“The family have to remain very cautious,” the source added.
Barry Gibb sang to Robin by his bedside and a source close to the family said this prompted “flickers of life”
Barry Gibb jetted into the UK from Tennessee to join other members of the family, following Robin’s re-admission to hospital.
Robin Gibb is now battling pneumonia, following months of health troubles, after being diagnosed with colon cancer after surgery for a blocked bowel in 2010.
In a recent interview, Robin Gibb’s wife Dwina said: “Barry was singing to him. Thousands of people are saying prayers every day.”
Last week, Dwina Gibb was spotted leaving the private hospital in Chelsea where her husband is fighting for his life.
Dwin Gibb’s been saying prayers at his bedside since he was admitted to hospital but she was pictured showing the strain of the past few days.
As she took a break from her vigil, the pained expression on her face spoke volumes.
Robin Gibb’s wife Dwina keeps vigil at his bedside in a private hospital in Chelsea, West London, UK, where the Bee Gee continues to fight for his life.
Robin Gibb, 62, has been in a coma since Friday, and doctors fear he has just days to live.
Bee Gees star is now battling pneumonia, following months of health troubles.
Robin Gibb was diagnosed with colon cancer after surgery for a blocked bowel in 2010, with the disease later spreading to his liver.
His latest setback comes after a series of operations and treatments, and amid reports of a new tumor.
Dwina Gibb, his children and Robin’s brother, Barry, have been praying at his bedside.
Robin Gibb’s wife Dwina arrives at the private hospital in Chelsea, where the Bee Gee continues to fight for his life
Robin Gibb’ son, Robin-John, 29 – known as RJ for short – said he would do “anything” to have his father make a swift and full recovery.
RJ said: “My dad has had a hard recovery from cancer.
“When you get rid of the cancer a lot of periphery problems can occur. This is so sad.”
RJ told The People that everyone from the family was “praying” for a recovery and that he felt honored to be living in his father’s shadow.
He added: “If people say that I’m living in my ¬father’s shadow, all I can say is what a great shadow that is to be living in.”
Robin Gibb made a recovery from liver and colon cancer this year, but doctors believe a second tumor may be present.
He has also developed pneumonia.
Robin Gibb revealed his battle with cancer in October 2010.
He had emergency surgery to treat a blocked bowel, before a further operation to treat a twisted bowel. Colon cancer was then discovered and it spread to his liver.
Robin Gibb’s twin brother Maurice died of complications resulting from a twisted intestine in 2003, aged 53.
[googlead tip=”patrat_mediu” aliniat=”stanga”]A new treatment for leukemia had amazing results, surprising even the researchers who designed it. The new treatment has eradicated the cancer cells present in the first three patients tested bodies.
Early results of a clinical trial showed that genetically engineered T cells eradicate leukemia cells and thrive.
Scientists from the University of Pennsylvania have genetically engineered patients’ T cells — a type of white blood cell — to attack cancer cells in advanced cases of a common type of leukemia.
The first two of three patients studied, who received the innovative treatment, have been cancer-free for more than one year. In the case of the third patient, over 70% of cancer cells were removed, according to the researchers.
"Microscopic image showing two T cells binding to beads, depicted in yellow, that cause the cells to divide. After the beads are removed, the T cells are infused into cancer patients." (Dr. Carl June / Pennsylvania Medicine)
“In just three weeks, tumors were destroyed, the effect being more violent than we ever have imagined,” said Dr. Carl June, one of the researchers involved in the study.
“Each cell can destroyed thousands of cancer cells,” said June, “each patient have been removed tumors from at least 900 grams.”
“A huge accomplishment”
[googlead tip=”vertical_mare” aliniat=”dreapta”] “This is a huge accomplishment — huge,” said Dr. Lee M. Nadler, dean for clinical and translational research at Harvard Medical School, who discovered the molecule on cancer cells that the Pennsylvania team’s engineered T cells target.
Innovative treatment is using patients’ own T cells, which are extracted from body cells and then genetically modified to attack cancer cells and to multiply and then reintroduced into patients’ blood.
Findings of the trial were reported Wednesday in the New England Journal of Medicine and Science Translational Medicine.
According to LA Times report, for building the cancer-attacking cells, the researchers modified a virus to carry instructions for making a molecule that binds with leukemia cells and directs T cells to kill them. Then they drew blood from three patients who suffered from chronic lymphocytic leukemia and infected their T cells with the virus.
When they infused the blood back into the patients, the engineered T cells successfully eradicated cancer cells, multiplied to more than 1,000 times in number and survived for months. They even produced dormant “memory” T cells that might spring back to life if the cancer was to return.
On average, the team calculated, each engineered T cell eradicated at least 1,000 cancer cells.
Side effects included loss of normal B cells, another type of white blood cell, which are also attacked by the modified T cells, and tumor lysis syndrome, a complication caused by the breakdown of cancer cells.
“We knew [the therapy] could be very potent,” said Dr. David Porter, director of the blood and marrow transplantation program at the Hospital of the University of Pennsylvania in Philadelphia and a coauthor of both papers, which were published in the New England Journal of Medicine and Science Translational Medicine.
“But I don’t think we expected it to be this dramatic on this go-around.”
Bone marrow transplants from healthy donors have been effective in fighting some cancers, including chronic lymphocytic leukemia, but the treatment can cause side effects such as infections, liver and lung damage, even death.
“1/5 of bone marrow transplant recipients may die of complications unrelated to their cancer,” Porter said.
Researchers have been working for many years to develop cancer treatments that leverage a patient’s immune system to kill tumors with much greater precision.
Specialists not involved in the trial said the new discovery is very important because it suggested that T cells could be adapted to destroy a range of cancer cells, including ones of the blood, breast or colon
“It is kind of a holy grail,” said Dr. Gary Schiller, a researcher from UCLA’s Jonsson Comprehensive Cancer Center who was not involved in the trial.
“It would be great if this could be applied to acute leukemia, where there is a terrible unmet medical need,” UCLA’s Schiller said.
Dr. David Porter added:
“Previously efforts to replace risky bone marrow transplants with such engineered T cells proved disappointing because the cells were unable to multiply or survive in patients.”
“This time, the T cells were more robust because the team added extra instructions to their virus to help the T cells multiply, survive and attack more aggressively.”
“About 15,000 patients are diagnosed with chronic lymphocytic leukemia every year. Many can live with the disease for years. Bone marrow transplants are the only treatment that eradicates the cancer.”
[googlead tip=”lista_mare” aliniat=”stanga”]Dr. David Porter cautioned that these were preliminary results and the scientists plan to continue the trial, treating more patients and following them over longer periods.
“The researchers also would like to expand the work to other tumor types and diseases,” Porter said.
The hope, scientists said, is that the method would work for cancers that can kill more ruthlessly and rapidly.