John McCain’s widow, Cindy, tweeted: “My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years. He passed the way he lived, on his own terms, surrounded by the people he loved, in the place he loved best.”
His daughter Meghan said the task of her lifetime would now be “to live up to his example, his expectations, and his love.
Following news of John McCain’s death, wellwishers waving flags lined the street as a hearse brought his body from his ranch near Cornville, Arizona, to a funeral home in Phoenix.
The six-term senator for Arizona and 2008 Republican presidential nominee was diagnosed after doctors discovered his tumor during surgery to remove a blood clot from above his left eye last July.
John McCain’s family said he would lie in state in Phoenix, Arizona, and in Washington DC before a funeral at the Washington National Cathedral and his burial in Annapolis, Maryland.
Former presidents George W. Bush and Barack Obama are expected to give eulogies.
According to US scientists, the harmful Zika virus that can cause devastating brain damage in babies could offer up a surprising new treatment for adult brain cancer.
Until now, Zika has been seen only as a global health threat – not a remedy.
However, latest research shows Zika virus can selectively infect and kill hard-to-treat cancerous cells in adult brains.
Zika injections shrank aggressive tumors in fully grown mice, yet left other brain cells unscathed.
Human trials are still a way off, but researchers believe Zika virus could potentially be injected into the brain at the same time as surgery to remove life-threatening tumours, the Journal of Experimental Medicine reports.
The Zika treatment appears to work on human cell samples in the lab.
There are many different types of brain cancer. Glioblastomas are the most common in adults and one of the trickiest to treat.
They are fast growing and diffuse, meaning they spread through the brain, making it difficult to see where the tumor ends and the healthy tissue begins.
Radiotherapy, chemotherapy and surgery may not be enough to remove these invasive cancers.
However, the latest research, in living mice and donated human brain tissue samples, shows Zika therapy can kill cells that tend to be resistant to current treatments.
It is thought that these glioblastoma stem cells continue to grow and divide, producing new tumor cells even after aggressive medical treatment.
Different, healthy stem cells are found in abundance in baby brains, which probably explains why regular Zika can be so damaging to infants, say the researchers.
Adult brains, however, have very few stem cells. This means Zika treatment should destroy only the cancer-causing brain stem cells without causing much collateral damage.
As an extra safety precaution, the research team from Washington University School of Medicine and the University of California San Diego School of Medicine has already begun modifying the virus to make it more tame than regular Zika.
Using viruses to fight cancer is not a new idea, but using Zika as the weapon of choice is.
UK scientists at the University of Cambridge are beginning similar trials with Zika.
The Charlatans drummer Jon Brookes has died aged 44.
Jon Brookes had suffered a seizure on tour with the band in 2010 and had been receiving treatment for a brain tumor.
He had undergone several operations, but had still been working on new material with the band over the summer.
Jon Brookes died in hospital on Tuesday morning with his family at his bedside.
The Charlatans frontman Tim Burgess tweeted that the band was “torn apart” at the news and sent love to Jon Brookes’s family.
“Jon Brookes, my friend, our drummer and inspiration to so many, passed away this morning. We are torn apart. Love & thoughts to Jon’s family,” he said.
Tim Burgess also thanked “everyone for their messages and memories of Jon Brookes. So much love on such a sad day”.
Jon Brookes had suffered a seizure on tour with the band in 2010 and had been receiving treatment for a brain tumor
A further statement from the band read: “Jon was a brilliant drummer, an inspiration, a founding member of The Charlatans, part of our family and a friend to everyone in and around the band.
“Losing someone who was always so full of life is a tragedy that will be shared by so many. Our thoughts are with Debbie and all of Jon’s family.”
Jon Brookes was diagnosed with a brain tumor after collapsing during a Charlatans gig in Philadelphia, in the United States in 2010.
He briefly stopped breathing and was helped by a doctor attending the show, before being taken to hospital for emergency treatment.
The rest of their US tour was cancelled as Jon Brookes was flown to the UK for treatment.
Speaking afterwards Jon Brookes described how he “saw lights” in the corner of his eyes before collapsing at the concert and said he was at the “start of the long road of treatment for cancer” but was “feeling fit and positive”.
In July this year the band revealed that Jon Brookes had undergone further surgery for the brain tumor.
They said he had recovered well from the operation but would remain in hospital for additional treatment.
Jon Brookes, of Burntwood, Staffordshire, was a founding member of the band that formed in the West Midlands in 1989.
Another original band member, keyboardist Rob Collins, died in a car accident in 1996.
The Charlatans have had 22 UK top 40 hits, including The Only One I Know, Can’t Get Out Of Bed and One To Another.
Elida-Marie Caraballo, the niece of sadistic Cleveland kidnapper Ariel Castro, has revealed how she innocently played in his “house of horrors” while his three torture victims were chained up in the cellar beneath her.
Elida-Marie Caraballo, 19, said she would visit “Uncle Ariel” with her cousin Arlene – Ariel Castro’s daughter – but he would demand they wait outside the back door until he “fixed things” inside.
“He would play the radio real loud and told me never to leave the kitchen,” she said.
“I thought he was weird but I had no idea he was a monster. It gives me chills to think I was playing with my toys on the kitchen floor while those poor girls were locked in the basement.
“My uncle and aunt were separated so I would go round with Arlene to visit her daddy.”
Elida-Marie Caraballo, 19, said she would visit “Uncle Ariel” with her cousin Arlene
Elida-Marie Caraballo’s mother, Elida, 44, is the sister of Ariel Castro’s common-law-wife Grimilda Figueroa who died last year of a brain tumor the family say was brought on by vicious beatings by Castro.
The couple bought the house where the three women were held captive, built in 1950, in 1992 and raised their four young children there until they split in 1996.
Elida-Marie Caraballo says her uncle’s behavior “became weirder” after he split from her aunt and that he may have abducted his victims to replace the family he lost.
“He was a bully and used to beat my aunt badly but when she finally got the courage to leave and come live with us he cried and begged her to come home.”
Recalling her visits there, Elida-Marie said: “I had no idea those poor girls were chained up in the basement.
“Now I wonder what would have happened if I’d heard something. Would he have locked me in the basement too? I was only a kid but the house gave me the creeps.”