David Rockefeller has died in his sleep at his home in Poncantico Hills, New York, a spokesman said.
The 101-year-old billionaire philanthropist, the last of his generation in the famed American family, was the grandson of Standard Oil co-founder John D. Rockefeller.
David Rockefeller was at the helm of his family’s fortune, controlling both philanthropic and business interests.
He was the youngest of five sons of John D. Rockefeller Jr.
Though he never sought political office, David Rockefeller had two brothers who served in government.
Nelson Rockefeller served as governor of New York and briefly as vice-president while Winthrop Rockefeller was the governor of Arkansas.
David Rockefeller graduated from Harvard in 1936 and received a doctorate in economics from the University of Chicago in 1940.
He then served in the army World War Two before working at Chase Bank, which later became JP Morgan Chase.
David Rockefeller was named president of the company in 1961 and chairman and chief executive in 1969.
The renowned capitalist supported the assistance of economies abroad, arguing that it would create customers for American products.
Under his leadership, Chase was the first US bank to open offices in the Soviet Union and China.
In 1974, it was the first to open an office in Egypt after the Suez crisis of 1956.
David Rockefeller was also behind the project that led to the World Trade Center in New York City.
He retired in 1981 at the age of 65.
Former President George H.W. Bush and his wife, Barbara, released a statement saying they were “deeply saddened” by the passing of their “wonderful friend”.
The statement read: “So many knew him as one of the most generous philanthropists – and brightest Points of Light – whose caring and commitment to the widest range of worthy causes touched and lifted innumerable lives.
“David was also very active in national and international affairs, and his connections and keen aptitude for issues made him a valuable advisor to Presidents of both parties – yours truly certainly included.”
The couple added that they would “surely miss” their annual visits with him in Maine.
David Rockefeller was also remembered for his patronage to philanthropy and the arts, preserving his family’s close relationship with the Museum of Modern Art.
His private art collection was once valued at $500 million.
On his 100th birthday in 2015, David Rockefeller donated 1,000 acres of land next to a national park to the state of Maine.
His charitable service earned him a Presidential Medal of Freedom, the country’s highest civilian honor, in 1998.
David Rockefeller had six children – David Jr., Richard, Abby, Neva, Margaret and Eileen – with his wife Margaret (nee McGrath). She died in 1996.