Nepal has been hit by a 7.9-magnitude earthquake in an area between the capital Kathmandu and the city of Pokhara, the US Geological Survey said.
The earthquake caused extensive damage to buildings and some injuries, eyewitnesses say.
Tremors were felt as far away as the Indian capital Delhi and other cities in northern India, which borders Nepal.
Several buildings, including temples are reported to have been reduced to rubble in Kathmandu.
Injured people have been brought to the main hospital. There has been no estimate yet on the number of deaths, but Reuters news agency reported that two people had died, one in Nepal, one in northern India.
Indian PM Narendra Modi wrote on Twitter: “We are in the process of finding more information and are working to reach out to those affected, both at home and in Nepal.”
Aftershocks could still be felt across the region sometime after the initial quake.
Kathmandu was all but destroyed in the devastating earthquake of 1934.