Russia and the US have agreed in Geneva that Syria’s chemical weapons must be destroyed or removed by mid-2014.
US Secretary of State John Kerry outlined a six-point framework under which Syria must hand over a full list of its stockpile within a week.
If Syria fails to comply, the deal could be enforced by a UN resolution backed by the threat of sanctions or military force.
The US says the Syrian regime killed hundreds in a gas attack last month.
The government of Bashar al-Assad denies the allegations and has accused the rebels of carrying out the attack.
In a joint news conference with Russian Foreign Minister Sergei Lavrov, John Kerry called on the Assad government to live up to its public commitments.
“There can be no room for games. Or anything less than full compliance by the Assad regime,” he said.
John Kerry and Sergei Lavrov said if Syria failed to comply, then a UN resolution would be sought under Chapter VII of the UN charter, which allows for the use of force.
The US Secretary of State said inspectors must be on the ground by November, and that the stockpiles should be removed or destroyed by mid-2014.
More than 100,000 people have died since the uprising against President Bashar al-Assad began in 2011. Millions of Syrians have been displaced.