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Male contraceptive pill could be developed after discovery of sperm formation gene Katnal1


A new male contraceptive pill could be developed after researchers in Edinburgh, UK, have identified a gene critical for the production of healthy sperm.

Experiments in mice found that the gene, Katnal1, was vital for the final stages of making sperm.

The authors of a study in PLos Genetics said a drug which interrupts Katnal1 could be a reversible contraceptive.

A fertility expert said there was “certainly a need” for such a drug.

Contraception in men is largely down to condoms or a vasectomy.

Experiments in mice found that gene Katnal1 was vital for the final stages of making sperm

Experiments in mice found that gene Katnal1 was vital for the final stages of making sperm

Researchers at the Centre for Reproductive Health at the University of Edinburgh were investigating the causes of male infertility.

They randomly altered the genetic code of mice to see which became infertile. They then traced the mutations which led to infertility, which led them to Katnal1.

It contains the blueprints for a protein which is important in cells which support the development of sperm. Without the protein, sperm do not fully form and the body disposes of them.

Scientists hope they will be able to perform a similar trick in humans to stop sperm developing, without causing lasting damage.

One of the researchers Dr. Lee Smith said: “If we can find a way to target this gene in the testes, we could potentially develop a non-hormonal contraceptive.


“The important thing is that the effects of such a drug would be reversible because Katnal1 only affects sperm cells in the later stages of development, so it would not hinder the early stages of sperm production and the overall ability to produce sperm.”

He said it would be “relatively difficult” to do as the protein lives inside cells, however, he said there was “potential” to find something else that protein worked with, which might be an easier target.