The odds of naturally conceiving quintuplets are one in several million, according to Dr. Wright Bates, from the University of Alabama.
Dr. Wright Bates told ABC News that quins are “exceedingly rare”.
He said twins are born in up to 1 in every 100 births, while triplets are 1 in every 7,000 to 10,000 births.
Naturally conceived quadruplets are born in every 1 in 600,000 births.
The first recorded set of quintuplets known to have all survived were the Dionne sisters, who were born in Ontario, Canada.
Fewer than 10 sets of quintuplets are born every year in the United States.
Last month, Guillermina and Fernando Garcia had five babies – three girls and two boys – who weighed between 2 to 3 pounds each at the University of Utah hospital in Salt Lake City for another six weeks.
In 2010, British mother Vicky Lamb had four girls and two boys after taking a fertility drug but sadly one of the babies died.