Trojan-horse therapy completely eliminates prostate cancer in experiments on mice
British researchers have found that an experimental “Trojan-horse” cancer therapy has completely eliminated prostate cancer in experiments on mice.
The team hid cancer killing viruses inside the immune system in order to sneak them into a tumor.
Once inside, a study in the journal Cancer Research showed, tens of thousands of viruses were released to kill the cancerous cells.
Experts labeled the study “exciting,” but human tests are still needed.
Using viruses to destroy rapidly growing tumors is an emerging field in cancer therapy, however one of the challenges is getting the viruses deep inside the tumor where they can do the damage.
“There’s a problem with getting enough virus into the tumor,” said Prof. Claire Lewis from the University of Sheffield.
She leads a team which uses white blood cells as “Trojan horses” to deliver the viral punch.
After chemotherapy or radiotherapy is used to treat cancer, there is damage to the tissue. This causes a surge in white blood cells, which swamp the area to help repair the damage.
“We’re surfing that wave to get as many white blood cells to deliver tumor-busting viruses into the heart of a tumor,” said Prof. Claire Lewis.
Her team takes blood samples and extract macrophages, a part of the immune system which normally attacks foreign invaders. These are mixed with a virus which, just like HIV, avoids being attacked and instead becomes a passenger in the white blood cell.
In the study, the mice were injected with the white blood cells two days after a course of chemotherapy ended.
At this stage each white blood cell contained just a couple of viruses. However, once the macrophages enter the tumor the virus can replicate. After about 12 hours the white blood cells burst and eject up to 10,000 viruses each – which go on to infect, and kill, the cancerous cells.
At the end of the 40-day study, all the mice who were given the Trojan treatment were still alive and had no signs of tumors.
By comparison, mice given other treatments died and their cancer had spread.
Prof. Claire Lewis said: “It completely eradicates the tumor and stops it growing back.”
She said it was a “ground-breaking” concept, but cautioned that many remarkable advances in treating mice failed to have any effect in people.
She hopes to begin human trials next year.
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